FUT2 and infection: Alternatively, DE genes may vary depending on the predominant otopathogen during infection: in other words, whether commensal or otopathogenic bacteria bind to ME mucosal epithelium via A antigen, the expression of which is affected by heterozygous or homozygous genotype for the FUT2 c.461G>A variant (Figures 6, 7; Santos-Cortez et al., 2018).