KMT2D mutations are the cause of the majority of cases of Kabuki syndrome (KS; MIM 147920) (Ng et al., 2010; Yap et al., 2020)KS patients have high rate of infections and array of immunological abnormalities (Hoffman et al., 2005)OM occurs in 55-90% of KS patients (Boniel et al., 2021). This evidence concerns the gene KMT2D and ocular melanoma.