In contrast, in our OM patients with the FUT2 stop variant, FN1 was downregulated (Figure 2 and Table 4), indicating that non-functional FUT2 might also affect the direction of regulation of the immune network that includes FN1 and also RASIP1, MTAP and MLL2/KMT2D (Figure 3). Here, KMT2B is linked to ocular melanoma.