Indeed, the augmentation of systemic markers due to periodontitis (D’Aiuto et al., 2007; Paraskevas et al., 2008; Lima et al., 2011; Fedele et al., 2011; Nibali et al., 2013; Shaddox et al., 2013; Balli et al., 2014; Keles et al., 2014; Finoti et al., 2017; Chandy et al., 2017; Batschkus et al., 2017), such as specific interleukins, fibrinogen, albumin, CRP, matrix metalloproteinase-9 or tumor necrosis factor-α, participate to the vascular endothelial weakening and its dysfunction (Tonetti et al., 2007) and, therefore, can promote systemic diseases. The gene discussed is MMP9; the disease is periodontitis.