MYC and B-cell chronic lymphocytic leukemia: Given the low frequency of CLL cases with MYC aberrations, and the low proportion of cells with MYC aberrations (in case of a subclonal abnormality) and thus the requirement for systematic screening with a fluorescent in situ hybridization (FISH) probe, it will be challenging to evaluate the prognostic impact of these two abnormalities in prospective trials of targeted therapies (e.g. BTKi and BCl2 inhibitors).