TP53 and B-cell chronic lymphocytic leukemia: The frequency of MYC gain is higher in CLL with del(17p) (ranging from 9% to 44%) (13, 14, 16–18), and we have demonstrated that the del(17p) + 8q24 gain combination (involving TP53 and MYC respectively) was associated with a very poor outcome within the del(17p) CLL.