There are two possibilities for this phenomenon: 1) tumor infiltrating CD8+ T lymphocytes express a variety of integrins, including CD49a, and remain in the TME in a quiescent/exhausted state, or 2) CD8+ T cells in the TME upregulate the expression of multiple integrins after exhaustion through an undetermined mechanism (Figure 2). The gene discussed is CD8A; the disease is neoplasm.