What’s more, TSLNC8 competitively interacts with transketolase (TKT) and STAT3, and modulates the STAT3-Tyr705 and STAT3-Ser727 phosphorylation levels and STAT3 transcriptional activity, thus resulting in the inactivation of the IL-6/STAT3 signaling pathway and suppressive growth of hepatocellular carcinoma (23). This evidence concerns the gene STAT3 and hepatocellular carcinoma.