WAS and hepatocellular carcinoma: For example, N-WASP, an important member of WASP, is highly expressed in HCC, and its elevated expression predicts a poor prognosis in HCC patients, and the potential mechanism maybe to promote prolongation of actin filament side branch polymerization by activating the Arp2/3 complex, which drives the formation of a bulge in the cell membrane and thus enhances cell migration (32, 33).