IGF1R and familial pancreatic carcinoma: Studies have confirmed that the knockdown of FAM21 inhibits the migration of prostate cancer cells, and its expression is regulated by the nuclear translocation of IGFR (15); in pancreatic cancer studies, nuclear FAM21 was found to regulate NF-κB transcription, and its reduced expression increased the sensitivity of pancreatic cancer cells to gemcitabine and pentafluorouracil (16); knockdown of FAM21 expression in breast cancer cells significantly reduced the ability of cells to degrade the extracellular matrix (17).