Furthermore, in our recent study, we found that in HCC cells, PIP2 can bind to CAPZA1, and the combination of the two led to disengaging CAPZA1 from the barbed end of F-actin, which in turn promoted the prolongation of F-actin and drove the morphogenesis of HCC cells (20). The gene discussed is CAPZA1; the disease is hepatocellular carcinoma.