By comparative analysis of the genetic landscape, we found that the mutation frequency of LRP1B, SMARCA4, STK11, FAT2, RBM10, FANCM genes in the old lung cancer group was significantly higher than that in the youth group, while EML4-ALK fusion, BCL2L11 deletion polymorphism in the young group was higher than that in the old group (Figure 3A, Fisher’s Exact Test, p ≤ 0.05). Here, ALK is linked to lung carcinoma.