When taking the driver gene into account, the results of MAFtools showed a more complex constitution of driver genes in the old group with KRAS, EGFR, CTNNB1, BRAF, PIK3CA, and TP53 compared to the young group with KRAS and EGFR only, which was in accordance with the relatively simple tumor genetic evolutionary pattern of the young lung cancer group. This evidence concerns the gene PIK3CA and lung cancer.