SFRP4 and metastatic malignant neoplasm in the lymph nodes: Previous studies showed that SFRP4 overexpression was linked to advanced tumor stage, high classical/quantitative Gleason grade (p < 0.0001 each), lymph node metastasis (p = 0.0002), and a positive surgical margin (p = 0.0017), and SFRP4 expression was an independent predictor of recurrence after prostatectomy (HR = 1.35; p = 0.009) (22, 37).