Recent studies have shown that tumor microenvironment is closely related to epithelial-mesenchymal transformation of cancer cells, and the interaction between them can promote epithelial-mesenchymal transformation in cancer cells (34), tumor-related macrophages, especially M2-type macrophages, can produce EMT-promoting cytokines, such as IL-6 (35), it can be considered that TAM may promote HCC dedifferentiation. This evidence concerns the gene IL6 and hepatocellular carcinoma.