Mechanically, the exogenous expression of HNF1α, HNF4α and FOXA3 in hepatocellular carcinoma cells promotes the endogenous expression of a variety of hepatocyte nuclear factors, including C/EBP, thus promoting the transformation of hepatocellular carcinoma cells into hepatocyte-like cells (23). The gene discussed is HNF4A; the disease is hepatocellular carcinoma.