The expression of HNF1β can up-regulate the expression of Notch1 and Hes1 of genes related to Notch signaling pathway, activate Notch pathway, activate EMT and enhance the stemness expression of hepatocytes, and promote the dedifferentiation of normal hepatocytes to cancer cells, resulting in hepatocellular carcinoma (11). This evidence concerns the gene HNF1B and hepatocellular carcinoma.