HNF1A and hepatocellular carcinoma: The concentration of HNF1α protein in rat liver tumor decreased, and the binding activity of HNF1 protein decreased in the process of transformation from well differentiated human hepatocellular carcinoma to poorly differentiated human hepatocellular carcinoma (HCC), the binding activity of HNF1α protein decreased in the process of transformation from well differentiated human hepatocellular carcinoma to poorly differentiated human hepatocellular carcinoma (22).