Overexpression of HeyL in LNCaP cells significantly enhanced bicalutamide resistance, while blocking HeyL signaling with letrozole (an aromatase inhibitor) rescued the sensitivity of cells to bicalutamide, suggesting that the activated HeyL-aromatase axis in PCa cells can enhance endogenous estrogenic effects, thus attenuating the sensitivity of PCa cells to bicalutamide by promoting PCSC properties. This evidence concerns the gene HEYL and posterior cortical atrophy.