High expression of combined expression of the 8 genes, KRT19, FKBP10, GSK3B, SPANXB1, FN1, MYO1D, ANO8 and ESM1 in breast cancer patients was associated with worse metastasis-free survival in breast cancer patients (combined expression: log rank P = 0.0159, HR = 1; KRT19: log rank P = 0.0075, HR = 1.45; FKBP10: log rank P = 0.0061, HR = 3.5; GSK3B: log rank P = 0.0130, HR = 2.15; SPANXB1: log rank P = 0.0306, HR = 1; FN1: log rank P = 0.0003, HR = 1.62; MYO1D: log rank P = 0.0245, HR = 2.36; ANO8: log rank P = 0.0415, HR = 1; ESM1: log rank P = 0.0049, HR = 1.71) (Figure 5). This evidence concerns the gene SPANXB1 and breast carcinoma.