In comparison of the clinicopathological characteristics between the MVI-positive and MVI-negative groups, eight variables, namely, clinical TNM stage, α-fetoprotein (AFP), Edmondson–Steiner classification, tumor size, tumor number, tumor capsule, tumor margin, and satellite nodule, were significantly associated with the MVI according to the univariate analysis (Table 1). This evidence concerns the gene AFP and neoplasm.