Furthermore, clinical TNM stage, Edmondson–Steiner classification, tumor size, tumor capsule, tumor margin, and AFP were found to be independent risk factors of MVI by multivariate analysis; interestingly, when MVI was present, three variables of tumor number, tumor capsule, and tumor margin were highly associated with M2 grade from the result of multivariate analysis (Table 3). Here, AFP is linked to neoplasm.