Our analysis also suggested that later clinical tumor stage, higher AFP, more advanced Edmondson–Steiner classification, larger tumor size, tumor capsule absence, non-smooth tumor margin, and multiple tumor number were significantly associated with MVI, and patients with MVI-M2 among these MVI-positive cases were more likely to have later clinical tumor stage, absent tumor capsule, non-smooth tumor margin, and multiple tumor number. Here, AFP is linked to neoplasm.