The univariate Cox regression model revealed that age at diagnosis (HR = 1.03, 95% CI = 1.017–1.044, P< 0.001), pathological stage (HR = 3.927, 95% CI = 2.847–5.417, P< 0.001), histological grade (HR = 2.679, 95% CI = 1.895–3.787, P< 0.001), and ACADSB expression (HR = 0.421, 95% CI = 0.331–0.535, P< 0.001) were associated with the OS of patients with ccRCC. The gene discussed is ACADSB; the disease is nonpapillary renal cell carcinoma.