Transcript differential expression analysis using DESeq2 revealed that ACADSB was significantly down-regulated in ccRCC tissues compared with normal kidney tissues in TCGA-KIRC (log2FC = -2.0, FDR < 0.001; Figure 2A), GSE36895 (log2FC = -1.7, FDR < 0.001; Figure 2B), and GSE53757 (log2FC = -2.2, FDR < 0.001; Figure 2C). Here, ACADSB is linked to nonpapillary renal cell carcinoma.