Thus, in tumors with large macrophage infiltrates, altering immune-suppressive characteristics into immune-promoting properties represents a promising approach for colon cancer treatment, as various strategies including targeting the anti-inflammatory cytokine IL-10, targeting pathogen recognition receptors and exogenous Beta-1,6 glucan supplementation have been reported in previous studies (49–51). Here, IL10 is linked to malignant colon neoplasm.