And HSPH1 was highly expressed in different tumors, such as colorectal cancer, B-cell lymphoma, melanoma and esophageal squamous cell carcinoma (31–34), while NAA25 knockdown could upregulate IFIT2 and NDRG1 expression and downregulate HSPH1 expression (Figure 3F). This evidence concerns the gene HSPH1 and colorectal cancer.