MED10 and neoplasm: Bioinformatics-aided evaluation of CRISPR-induced loss of MED10 function (criMED10) in 29 BLCA cell lines showed that increased suppression of med10 elicited increased downregulation of hsa-miR-590 copy number in metastatic cell lines 253J, UMUC1, UMUC13, UMUC14, and JMSU1 (Spearman r = 0.30) compared with the apparent non-effect in primary tumor cell lines (Spearman r = -0.003) (Figure 5D).