MTOR and tuberous sclerosis: In particular, alterations in mTORC1 activity caused by tuberous sclerosis mutations are associated with Alzheimer’s disease, and since RPP25 was previously mentioned as a systemic sclerosis-related gene and we also found through KEGG functional enrichment analysis that RPP25 is mainly enriched in Alzheimer’s disease–related pathways, we can also speculate that RPP25 is in GBM perhaps by affecting mTOR signalling pathways in GBM.