In contrast to another previous report (2), we found that LCNEC patients had better survival compared to patients with classic LCC, which might be associated with the enrichment of RB1 and BRAF mutations in the LCNEC group and the enrichment of SMARCA4 and KEAP1 mutations in the LCC group. This evidence concerns the gene SMARCA4 and leukoencephalopathy with calcifications and cysts.