An incidence greater than 10% includes reactive capillary endothelial proliferation (RCCEP, n=15; 48.4%), total bilirubin increase (n=13; 41.9%),TSH increase (n=13; 41.9%), hypothyroidism (n=9; 29%), alanine aminotransferase increase (n=8; 25.8%), aspartate aminotransferase increase (n=7; 22.6%), proteinuria (n=7; 22.6%), hypertension (n=6; 19.4%), cardiac troponin (n=5; 16.1%), hyperthyroidism (n=4; 12.9%), hand-foot syndrome (n=4; 12.9%), and diarrhea (n=4; 12.9%). The gene discussed is GPT; the disease is hypothyroidism.