By comparing the results obtained for untreated PBMCs of FMF patients and healthy controls, a significant increase was observed in the expression of NLRP3 (0.40±0.098, P=0.0013), MEFV (0.45±0.053, P<0.0001), CASP1 (0.59±0.09, P=0.0137), and IL-1β (0.45±0.09, P<0.0001). The gene discussed is IL1B; the disease is familial Mediterranean fever.