Several studies have already illustrated the anti-inflammatory and anti-tumor effects of parthenolide(PTL) and its derivatives which inhibit the activity of Nuclear factor-κB (NF-κB), NLR family Pyrin domain containing 3 (NLRP3), and cysteine-aspartic acid protease 1(Caspase1) (15, 16). The gene discussed is NLRP3; the disease is neoplasm.