IL18 and familial Mediterranean fever: As shown in Figure 4, DMAPT significantly reduced secretion levels of IL-1β (8.92±5.3 vs. 149.85±20.92, P<0.0001), IL-18 (135±32.1 vs. 192±22.18, P=0.01) and IL-37 (27.5±6.3 vs. 78.19±14.3, P<0.0001) in PBMCs of FMF patients as compared to untreated cells, respectively.