That is a punishment strategy for Mtb, because (i) low levels of TGF-β and IDO lead to a decrease in immune system over-reaction by inhibiting harmful inflammation; (ii) change of CCR1 from the medium to the high level, consequently led to decreased CFP-10, as activation of this pathway recruits Th1 lymphocytes to the site of infection, which are the most powerful arm of the immune system to combat intracellular invaders. This evidence concerns the gene CCR1 and infection.