Although early analysis of chemokines in vitiligo indicated that the expression of chemokines, such as CXCL9 and CXCL10, could be reliable biomarkers for disease activity and prognosis, emerging studies have shed light on the interaction between the increased ROS levels and levels of several chemokines, such as CXCL16 and CXCL10, to act as key effectors in the initiation and progression of vitiligo [10]. The gene discussed is CXCL9; the disease is vitiligo.