However, CXCL8 has also been proposed as a powerful chemokine to indirectly induce the apoptosis of melanocytes and keratinocytes through oxidative stress, and the apoptotic cells can release proinflammatory cytokines and chemokines, which may favor the cutaneous infiltration of immune cells in vitiligo [62, 63]. Here, CXCL8 is linked to vitiligo.