In vivo, a “cocktail” of certain stimuli including bacterial LPS, as a primary and early stimulus, as well as pro-inflammatory, airway-cell-produced cytokines like IL-1β and TNF-α as a secondary stimulus, could be responsible for the synthesis of A20 in the lung in the chorioamnionitis model. The gene discussed is TNFAIP3; the disease is chorioamnionitis.