PBRM1 and nonpapillary renal cell carcinoma: Specifically, ACACA, FBP1, BAP1, FH, HIF1A, KRAS, MTOR, VHL, PBRM1, PRKAA1, and SETD2 were downregulated, while ACLY, AKT1, MYC, G6PD, HIF2A, SLC2A1, and TP53 were upregulated in ccRCC tissues compared with normal tissue (Figure 2(a)).