Then, six prognostic DERGs including ALDH6A1, ALDH1L1, SHMT1, GLRX5, ALDH1A3, and GSTM3 were identified (Figure 1(c)), and all genes were significantly downregulated in ccRCC patients (P < 0.001; Figure 1(d)). The gene discussed is SHMT1; the disease is nonpapillary renal cell carcinoma.