Meanwhile, the phosphorylation of phosphatidylinositol-3kinase (P13K)/protein kinase B (Akt), which is involved in promoting cell growth and proliferation, decreased [49], suggesting that Notch1 simultaneously regulates the proliferation and apoptosis of tumor cells and inhibits Notch1 signaling, which may be a new therapeutic target. This evidence concerns the gene AKT1 and neoplasm.