The expression of dry markers, such as copper transporter (CTR2), BC1-2, oct4-binding protein (OCT4), Kruppe1-like factor 4 (KLF4), and multidrug resistance gene (MDRl), was downregulated, and the abilities of self-renewal, tumor formation, invasion, and migration were reduced, and the sensitivity to sorafenib and cisplatin increased [54]. The gene discussed is KLF4; the disease is neoplasm.