As shown in Figure 4(a), scatter diagram between MM and GS exhibited a significant correlation between intramodular connectivity and genetic phenotypes in the coexpression modules (blue: correlation coefficient = 0.96, p < 1e − 200; brown: correlation coefficient = 0.68, p = 6.2e − 65; green: correlation coefficient = 0.46, p = 4.8e − 07; turquoise: correlation coefficient = 0.81, p < 1e − 200; yellow: correlation coefficient = 0.25, p = 0.0079), suggesting that the five coexpression modules were prominently associated with low expression of PIK3CB in AD patients. The gene discussed is PIK3CB; the disease is Alzheimer disease.