In the rat model of subarachnoid hemorrhage, ErbB4-induced activation of PIK3CB increased yes-associated protein (YAP) expression, a terminal effector of Hippo signaling that dramatically improved neurological deficits and apoptosis; meanwhile, inhibition of ErbB4 or YAP knockdown could eliminate this anti-apoptotic effect [72]. The gene discussed is PIK3CB; the disease is subarachnoid hemorrhage.