MBD2 increases HIF-1α in neutrophil-dominant asthma and is involved in increased differentiation and secretion of Th17 cells and IL17 through regulating the HIF-1α expression [143] and also reduces the Treg function through an increase in HIF-1α suggesting the epigenetic role of MBD2 in severe asthma [141]. The gene discussed is MBD2; the disease is asthma.