PDGFB and cancer: The mechanism study is mainly reflected in the increase of reactive oxygen species (ROS) in cancer cells for the further promotion of apoptosis [18] and epithelial-mesenchymal transformation (EMT) [18, 19] and to promote the expression of vascular growth factor, including matrix-derived factor-1 (SDF-1), VEGF, and platelet-derived growth factor B (PDGFB), among others [20, 21].