To determine whether CA can regulate glioma cell apoptosis through the Pi3k/Akt pathway under the condition of tumor anoxic microenvironment, the tumor anoxic microenvironment was pretreated with CoCl2 (100 μM) for 24 hours, while the control group was treated with CA 8 μg/ml. This evidence concerns the gene AKT1 and central nervous system cancer.