CAPN1 and cardiac hypertrophy: Han et al. [8] similarly found that simvastatin improved myocardial hypertrophy in diabetic rats by attenuating oxidative stress and inflammatory responses by calpain-1-mediated activation of NF-κB. Wang et al. [12] demonstrated that bacitracin inhibited pathological myocardial hypertrophy by blocking the NF-κB signaling pathway.