Physical indicators showed that compared with the control group, the weight of rats in the T2DM group was dramatically reduced after STZ injection (Figure 1(d)), resulting in increased HW/BW (Figure 1(e)) and LVW/BW ratios (Figure 1(f)), as well as the evidently increased mRNA expression of ANP and BNP, cardiac hypertrophy-specific markers (Figure 1(g)). Here, NPPA is linked to cardiac hypertrophy.