By the GO analysis and KEGG pathway enrichment analysis, the preventive effects of Yangxinshi on CF in DCM were complex, versatile characteristics of multitargets and multipathways, mainly through biological processes such as intracellular receptor signaling pathway, intracellular steroid hormone receptor signaling pathway, key pathways such as regulation of signaling by CBL, CD28 co-stimulation, FCERI-mediated MAPK activation, among which CBL pathway has the highest weight. Here, CBL is linked to familial dilated cardiomyopathy.