High STC2 expression in CRC tissues showed a statistically significant relation with histological tumor grade (P<0.001), tumor depth of invasion (T stage) (P=0.004), lymph node metastasis (N stage) (P=0.001), Dukes’ stage (P<0.001), lymphovascular invasion (P<0.001), and perineural invasion (P<0.001). The gene discussed is STC2; the disease is colorectal carcinoma.