TWIST1 and colorectal carcinoma: These studies indicated that STC2 gene silencing in CRC cells inhibits cell viability, invasion and migration, while STC2 over-expression increases EMT as it activates the phosphorylation of ERK, MEK and AKT signaling pathways, increases N-cadherin, vimentin and TWIST, decreases E-cadherin and upregulates P-glycoprotein.