STC2 and rectal cancer: To the best of our knowledge, only one recent study was performed to evaluate the immunohistochemical expression of STC2 in colon and rectal cancer and its relation to the tumor clinicopathological features by Zhang et al., and concluded that STC2 is an independent prognostic factor in colorectal cancer patients and the elevated STC2 expression is strongly correlated with the presence of nodal and distant metastasis, advanced clinical stage, and worse clinical outcome (15), and the results of this study was compared to that of Zhang et al., study.