These miRNAs directly target NEK6 mRNA and downregulate NEK6 expression, including miR-506-3p, miR-219-5p, and miR-141-3p, resulting in inhibition of cell proliferation and induction of apoptosis in retinoblastoma, HCC, and clear cell renal cell carcinoma [13, 20, 35]. The gene discussed is NEK6; the disease is clear cell renal carcinoma.