After being treated with G15 for 48 h, the migratory (Figures 3(c)–3(f)) and invasive (Figures 3(g)–3(i)) ability decreased and increased after G1 treatment in BGC-823 and HGC-27 cells, indicating that GPR30 might regulate the biological behavior of GC cells. Here, GPER1 is linked to gastric cancer.