In summary, six CEGs, including CCDC124, NR2C2AP, SLC25A39, DDX49, KXD1, TXNL4A, showed promising diagnostic and prognostic significance (AUC>0.90; HR > 1.40, p < 0.05), which may indicate showing its attractive research value in HCC. This evidence concerns the gene DDX49 and hepatocellular carcinoma.