PSEN1 and colorectal cancer: Dysregulation of presenilin-1 (PSEN1), the dominant component of γ-secretase complex, is a key regulator in tumorigenesis and progression, participating in biological and pathological processes of colorectal cancer, bladder cancer, liver cancer, and so on (Dabrowska et al., 2011; Deng et al., 2015; Ma et al., 2018).