Ye et al. (2017) disclosed that CREB1 is markedly increased in colorectal cancer and plays as an oncogene. Li et al. (2020) reported similar findings that forced expression of CREB1 reversed repressive effect of miR-383 on colorectal cancer cell proliferation and glycolysis, as well as promotion effect on cell apoptosis. Moreover, CREB1 silence hinders cell proliferation and EMT in prostate cancer (Wang et al., 2017). This evidence concerns the gene CREB1 and Familial prostate cancer.