Metadherin (MTDH) facilitated transcription by regulating transcription factors such as HIF1A and TWIST1 to control cancer cell migration, invasion, and angiogenesis, which was correlated with poor OS in many types of cancers, but it enhanced the vulnerability of tumor cells to ferroptosis through inhibiting GPX4 and SLC3A2 (Lu et al., 2018; Bi et al., 2019). This evidence concerns the gene GPX4 and cancer.