KRAS was the most commonly mutated oncogene in lung, pancreatic, and colorectal carcinomas and enabled an improved rate of glutathione regeneration and ferroptosis protection by elevating nicotinamide adenine dinucleotide phosphate hydrogen levels through metabolic reprogramming (Pylayeva-Gupta et al., 2011; Bebber et al., 2020). Here, KRAS is linked to colorectal carcinoma.