For paired normal and cancer tissues, the same difference in CALM1 mRNA expression was verified in kidney renal papillary cell carcinoma (KIRC; P < 0.001), HNSC (P < 0.001), COAD (P < 0.001), KICH (P < 0.001), kidney clear cell carcinoma (KIRC; P < 0.001), LUAD (P < 0.001), PRAD (P < 0.001), READ (P = 0.031), STAD (P = 0.004), and thyroid carcinoma (THCA; P < 0.05) (Figure 1B). The gene discussed is CALM1; the disease is cancer.