CALM1 and central nervous system cancer: However, CALM1 mRNA expression is decreased in colon adenocarcinoma (COAD; P < 0.001), kidney chromophobe (KICH; P = 0.001), lower grade glioma (LGG; P < 0.001), lung adenocarcinoma (LUAD; P < 0.001), prostate adenocarcinoma (PRAD; P < 0.001), and rectum adenocarcinoma (READ; P < 0.001) (Figure 1A).