MMP2 and neoplasm: Our current findings are in line with the available reports wherein in vitro/in vivo models have shown that chrysin inhibits tumor metastasis by decreasing the expression of MMP9 and MMP2 as well as COX-2 and i-NOS, and modulates the PI3K/AKT signaling pathway (Yang et al., 2014; Xia et al., 2015; Koosha et al., 2016; Zam and Khadour, 2017).