TIMP3 and cancer: Interestingly, this is the very first time it has been reported that chrysin treatment significantly decreases the methylation levels at the promoter region of several TSGs viz APC, CDH1, CDH13, BRCA1, CDKN2A, DAPK1, FHIT, GSTP1, MGMT, MLH1, PTEN, RARB, RASSF1, SOCS1, TIMP3, and WIFI (Figure 6B and Table 4), which are found to be hypermethylated in many cancers and have critical roles to play in various cellular processes (Mukherjee et al., 2015).