Extensive terms well-known to be associated with cancer such as ATF6-mediated unfolded protein response (Lin et al., 2021), blood vessel development (Carmeliet and Jain, 2011), regulation of cell cycle process (Evan and Vousden, 2001), focal adhesion (Eke and Cordes, 2015), PI3K-Akt signaling pathway (Martini et al., 2014), cellular senescence (Campisi, 2013) and FoxO signaling pathway (Farhan et al., 2017) are presented across multi-cancer types, further supporting the associations of ca-tRFs with the cancer-related functions. The gene discussed is ATF6; the disease is cancer.