There is scarce data according to PC but in other tumors such as bladder cancer, high messenger RNA expression of NRP2, NRP1, PDGFC, and PDGFD are associated with a more aggressive disease (i.e., a high T stage, positive lymph node status and reduced survival) (Förster et al., 2021). The gene discussed is PDGFD; the disease is pachyonychia congenita.