miR-93-5p has been previously reported in PC associated with lymphatic dissemination in locally advanced PC (Pudova et al., 2020), or combined with E2F2 (E2F transcription factor 2), RRM2 (ribonucleotide reductase regulatory subunit M2), and PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) genes and other three miRNAs (hsa-mir-17-5p, hsa-mir-20a-5p, hsa-mir-92a-3p), which marked this miRNA with promising therapeutic options in PC (Wei et al., 2020). The gene discussed is E2F2; the disease is pachyonychia congenita.