The expression of some immune depletion molecules, such as TGFB1 and vascular endothelial growth factor (VEGFA), in the CIP group were significantly lower than that in the Control group (P < 0.05; Figure 5A), while the CIP group showed lower expression of TNFSF4, TLR4, CD27, TNFRSF14, ICOSLG, CXCL10, TNFSF15, TNFRSF18, and HMGB1. The gene discussed is HMGB1; the disease is hereditary sensory and autonomic neuropathy.