In the adjuvant arthritis (AA) rat model, the NALP1 inflammasome was activated, and carboxyamidotriazole (CAI) reduced proinflammatory cytokine secretion by inhibiting the NF-κB signaling pathway and suppressing NALP1 activation, which may be beneficial for RA treatment (122). The gene discussed is NLRP1; the disease is rheumatoid arthritis.