A recent study showed that IL-6 could induce activation of the NLRP3 inflammasome via the cathepsin B (CTSB)/S100A9-mediated pathway and promote joint inflammation in CIA mice, suggesting that the IL-6/NLRP3 pathway may also be a novel target for RA therapy (110). The gene discussed is NLRP3; the disease is rheumatoid arthritis.