This is the case of CENPJ where mutations are associated with microcephaly and Seckel syndrome (96, 97); citron kinase whose loss of activity leads to human microcephaly (98), and a malformative syndrome in mice (99); as well as β-PIX and GIT1 where mutations have been linked to intellectual disability and microcephaly (100–104). The gene discussed is GIT1; the disease is Seckel syndrome.