In the CLP-induced sepsis model, EA at ST36 decreased the circulating d-lactose in serum, which means intestinal permeability, and increased IgA level, percentage of CD3+, γ/δ, CD4+, CD8+ T lymphocytes, and the ratio of CD4+/CD8+ T cells in intestinal mucosa cells. This evidence concerns the gene CD4 and Sepsis.