For example, the recently published literature by Qian has determined that miR-1246 was upregulated in hypoxia glioma-derived exosomes (H-GDE) and GBM patients’ cerebrospinal fluid (CSF), and delivery of H-GDE-derived miR-1246 contributed to inducing M2 macrophage polarization through targeting telomeric repeat binding factor 2 interacting protein (TERF2IP). Here, TERF2IP is linked to central nervous system cancer.