MMP2 and central nervous system cancer: This move could also repress glioma metastasis through reducing expression of Matrix metalloproteinase-2 (MMP-2), and induce carcinoma cells apoptosis via decreasing levels of B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein, and increasing expression levels of BCL-2 associated X (BAX), a pro-apoptotic protein (143).