Variable changes of other B cell subsets including immature/transitional B cells (CD20+CD10+ and CD20+/IgM+/CD10+), unswitched memory B cells (CD20+/CD27+/IgM+) and B cells associated with autoimmunity (CD19+/CD23low/CD38low) were also observed. The gene discussed is CD27; the disease is Autoimmunity.