In this regard, analysis of the public repository Pathobiology of Early Arthritis Cohort (PEAC) RNA-Seq Data (https://peac.hpc.qmul.ac.uk) (63) shows that ARNO is up-regulated in SFs from leukocyte-rich RA patients, compared with leukocyte-poor RA phenotypes and cells from less inflammatory osteoarthritis (11). The gene discussed is CYTH2; the disease is osteoarthritis.