The EULAR/ACR classification criteria for SLE (2019) necessitates at least one positive ANA for entry (6), followed by additive weighted criteria which is grouped in seven clinical domains (constitutional, hematological, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, and renal) and three immunological domains (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) that are weighted from 2 to 10 points. This evidence concerns the gene BTG3 and systemic lupus erythematosus.