From 1,316 ERGs, we found 220 genes expressed differently between tumor and normal samples and finally identified 10 genes (FBN1, HIC1, SFRP4, COL11A1, ONECUT2, HOXB9, DLX4, MSX1, TNF, and SIX1) associated with the prognosis of EC to establish a predicting model. The gene discussed is ONECUT2; the disease is neoplasm.