From 1,316 ERGs, we found 220 genes expressed differently between tumor and normal samples and finally identified 10 genes (FBN1, HIC1, SFRP4, COL11A1, ONECUT2, HOXB9, DLX4, MSX1, TNF, and SIX1) associated with the prognosis of EC to establish a predicting model. Here, SIX1 is linked to neoplasm.