From 1,316 ERGs, we found 220 genes expressed differently between tumor and normal samples and finally identified 10 genes (FBN1, HIC1, SFRP4, COL11A1, ONECUT2, HOXB9, DLX4, MSX1, TNF, and SIX1) associated with the prognosis of EC to establish a predicting model. This evidence concerns the gene SFRP4 and neoplasm.