MAPT and Alzheimer disease: Typical CSF findings for some dementias caused by proteinopathies include: reduced amyloid-β, increased tau and P−tau in AD; reduced α−synuclein for Lewy body dementia; real-time quaking-induced conversion, increased 14−3−3 protein, neuron-specific enolase, and tau for Creutzfeldt–Jakob disease (81).